The third-seeded former world No. 1 Federer defeated Kazakhstan's Mikhail Kukushkin 7-6 (7-2), 6-4, 6-2 on the famed Centre Court at the All England Club. The Swiss great advanced in 1 hour, 42 minutes by striking 53 winners, including 12 aces, and holding his serve throughout.
"The first match at Wimbledon is never easy really because we don't get any practice time on Centre Court," Federer said. "I thought I struggled putting enough returns into play in the first set but I thought he played well. For a set and a half he made it hard for me. I also served really well so I was very pleased with the match."
Federer is now 56-6 lifetime at Wimbledon, where he's reached the final seven times, with his only loss coming at the hands of current world No. 1 Rafael Nadal in the 2008 final, which marked one of the greatest tennis matches of all-time.
The 29-year-old Federer was stunned by Czech Tomas Berdych in the Wimbledon quarters a year ago.
Federer is the men's all-time record-holder with 16 major titles, but hasn't captured one since last year's Australian Open. He is trying to become only the second man in the Open Era (since 1968) to win seven Wimbledon titles. American legend Pete Sampras holds the record.
The iconic Federer's second-round opponent will be France's Adrian Mannarino.
The eighth-seeded former U.S. Open champion Roddick got past lefthanded German qualifier Andreas Beck 6-4, 7-6 (8-6), 6-3 in an efficient effort on Court 1. The big-serving Roddick uncorked 30 aces in the 2-hour, 15-minute affair, which was postponed here on Monday because of rain.
Roddick was tested in a 62-minute second set, but the match was never really in doubt for the veteran American, who was the beneficiary of 34 unforced errors from Beck. Roddick broke his German counterpart three times, while Beck was unable to break Roddick's formidable serve.
"The second set tiebreak was big for me because there's a big difference between two sets up and one-set all," Roddick said.
The 28-year-old Roddick, who's been slowed by injuries this season, is now 38-10 lifetime on the grass at the All England Club.
"I'm pretty happy with where my game is right now," Roddick said. "I feel healthy and I know what it takes to go deep at this tournament."
Roddick lost to Federer in finals here in 2004, 2005 and 2009. The loss to Federer here two years ago was particularly tough, as the former world No. 1 American succumbed in an epic 30-game fifth set on Centre Court.
Up next for Roddick will be Romanian Victor Hanescu.
In a rematch of their record-obliterating first-round Wimbledon match from a year ago, John Isner once again beat Nicolas Mahut, this time in straight sets, and in one day.
Last June, Isner and Mahut broke several tennis records in their opening-round odyssey that was played out over three days and took 11 hours and five minutes of court time to decide a weary winner.
The 6-foot-9 American Isner topped the French Mahut 7-6 (7-4), 6-2, 7-6 (8-6) in just over two hours this time around.
Last year's epic was staged on Court 18, while the 2011 rematch was held on the brand-new Court 3 at the All England Club.
Court 18 now features a plaque commemorating the 2010 occasion.
Isner converted on his second match point Tuesday when Mahut sent one final forehand long. The two players combined for a mere 16 aces (8-8) this year, compared to last year's mind-boggling 216-ace onslaught, which included a record 113 bombs from the Georgia native Isner in the longest tennis match in history.
Last year's Isner-Mahut marathon was decided in an incredible record 138- game fifth set, which the American ultimately won, 70-68.
Up next for the towering Isner will be 16th-seeded Spaniard Nicolas Almagro, who beat Finnish veteran Jarkko Nieminen 6-7 (5-7), 6-3, 6-4, 6-4.
Fifth-seeded Robin Soderling staved off capable German Philipp Petzschner 6-4, 6-4, 2-6, 7-6 (7-5), while seventh-seeded Spaniard David Ferrer rolled into the second round with a 6-4, 6-4, 6-4 handling of France's Benoit Paire on Tuesday. Soderling is a two-time French Open runner-up who reached the Wimbledon quarters last year.
Eleventh-seeded Austrian Jurgen Melzer overcame Colombian Alejandro Falla 3-6, 7-6 (7-5), 6-2, 6-2, while 12th-seeded Frenchman Jo-Wilfried Tsonga bested Japan's Go Soeda 6-3, 7-6 (7-4), 6-2.
Meanwhile, 13th-seeded Serb Viktor Troicki overcame Argentine Maximo Gonzalez 3-6, 6-0, 7-6 (7-3), 6-3; 15th-seeded former top-10 star Gilles Simon moved on with a come-from-behind 4-6, 6-4, 6-3, 7-6 (7-3) victory over fellow Frenchman Edouard Roger-Vasselin; 18th-seeded Russian Mikhail Youzhny outlasted Argentine Juan Monaco 4-6, 6-2, 6-2, 4-6, 6-4; 19th-seeded Frenchman Michael Llodra doused Brit James Ward 6-3, 7-6 (7-4), 6-3; 20th-seeded German Florian Mayer bested Brit Daniel Evans 7-6 (7-5), 7-6 (7-1), 3-6, 6-4; former top-10 star Fernando Gonzalez, on the mend from hip surgery, knocked out 22nd-seeded Ukrainian Alexandr Dolgopolov 6-3, 6-7 (6-8), 7-6 (7-3), 6-4; and 24th-seeded former world No. 4 Juan Martin del Potro handled Italian Flavio Cipolla 6-1, 6-4, 6-3 in a match that was suspended because of rain here on Monday. The 6- foot-6 Argentine del Potro was the 2009 U.S. Open champ who missed most of last season, including Wimbledon, following wrist surgery.
Fernando Verdasco, seeded 21st, went the distance to overcome Czech veteran Radek Stepanek 2-6, 4-6, 6-3, 7-6 (8-6), 9-7, while towering 6-foot-10 Croat Ivo Karlovic took out 23rd-seeded Serb Janko Tipsarevic 7-5, 3-1, retired and former top-five player Ivan Ljubicic dismissed 27th-seeded fellow Croat Marin Cilic 7-6 (7-2), 3-6, 6-3, 6-4 on Day 2 of this fortnight.
Former Wimbledon runner-up David Nalbandian moved on with a 7-5, 6-2, 6-3 victory over German Julian Reister. The 28th-seeded former top-five star from Argentina reached the final here back in 2002.
Also advancing were 25th-seeded Argentine Juan Ignacio Chela, 26th-seeded Spaniard Guillermo Garcia-Lopez and 32nd-seeded Marcos Baghdatis, who edged out American James Blake 6-4, 6-2, 6-7 (5-7), 4-6, 6-4.
Promising Aussie Bernard Tomic took out 29th-seeded former top-five star Nikolay Davydenko in straight sets.
Several other man advanced Tuesday, including American Ryan Harrison, Belgian Xavier Malisse and former champion Lleyton Hewitt of Australia. The oft-injured former world No. 1 Hewitt held off Japan's Kei Nishikori 6-1, 7-6 (7-4), 6-7 (7-9), 6-3. The two-time Grand Slam champion Hewitt titled at the All England Club in 2002, beating Nalbandian in the finale.
Hewitt should have his hands full with Soderling on Thursday.
Forty-five men's matches were on the schedule Tuesday after rain wreaked havoc at the All England Club on Monday.
The second round will get underway on Wednesday, including matches for a top-seeded Nadal, fourth-seeded Aussie Open runner-up Andy Murray of Great Britain, a sixth-seeded Berdych, and Roddick.
The reigning Wimbledon, French Open and U.S. Open champion Nadal will meet American Ryan Sweeting, while the two-time Wimbledon semifinalist Murray will encounter German Tobias Kamke. Nadal has won his last 15 matches at Wimbledon, having titled here in 2008, skipped the 2009 edition due to injury, and titled here for a second time last year by beating Berdych in the final.
Also slated for second-round action on Wednesday are 10th-seeded American Mardy Fish and the aforementioned del Potro. Fish will face Uzbekistan's Denis Istomin, while del Potro will be opposed by diminutive Belgian Olivier Rochus.
The 2011 Wimbledon champion will take home $1.78 million.