Vasek Pospisil, the last Canadian standing in singles play at the U.S. Open, was ousted with a second-round loss Friday.

The 21-year-old from Vancouver dropped a heartbreaking 5-7, 6-4, 7-6 (7-3), 7-6 (7-5) decision to 25th seeded Feliciano Lopez of Spain, ending Canada's hopes at Flushing Meadows.

Pospisil, ranked 143rd in the world, took the first set before Lopez bounced back to even it in the second. But the last two sets needed tiebreaks to decide, with the Spaniard coming out on top in both.

Lopez had 21 aces and seven unforced errors while Pospisil had 19 aces and eight unforced errors.

Hours after Pospisil lost, Canadian Daniel Nestor and Max Mirnyi of Belarus were upset 6-3, 7-5 in the second round of men's doubles by Brits Colin Fleming and Ross Hutchins. Nestor and Mirnyi were the second seeds.