SHANGHAI -- Top-seeded Rafael Nadal was upended by German Florian Mayer, while reigning champion Andy Murray and former world No. 1 Andy Roddick avoided third-round upsets Thursday at the $3.24 million Shanghai Masters tennis event.
The 15th-seeded Mayer doused the former Shanghai runner-up Nadal in 7-6 (7-5), 6-3 fashion at Qizhong Tennis Center.
Nadal saved a pair of set points while serving at 4-5 in the opening stanza, but he then gave away several points in the tiebreak, which Mayer closed out via ace.
The German secured the first break of the match to go up 4-3 in the second set and converted on another break point on match point to pull off the upset.
Mayer broke the mighty Spaniard twice on Day 5, while Nadal was unable to break the recent Bucharest titlist from Germany in the setback. Nadal did not enjoy even one break-point chance in the surprising loss, as he failed to reach a quarterfinal for only the second time this year.
This marked the first-ever ATP-level meeting between the 10-time Grand Slam champion Nadal and Mayer, who captured his first-ever ATP title in Romania last month.
The former No. 1 Nadal was this year's French Open champion and Wimbledon and U.S. Open runner-up. He was the 2009 runner-up here in Shanghai and lost to Murray in last week's marquee finale in Tokyo.
Nadal is the all-time leader with a whopping 19 Masters titles.
The second-seeded world No. 4 Murray, meanwhile, resumed his winning ways with a 6-4, 3-6, 6-3 victory over 13th-seeded Swiss Stanislas Wawrinka on Thursday.
The 2011 Australian Open runner-up Murray topped Swiss icon Roger Federer in last year's Shanghai finale. The British star is seeking his third straight title on the tour's Asian swing. In addition to his Tokyo championship last week, he also titled in Bangkok two weeks ago.
Murray's quarterfinal opponent on Friday will be Aussie qualifier Matthew Ebden.
A 10th-seeded Roddick reached the round of eight here with a 6-3, 6-4 upset of seventh-seeded Spaniard Nicolas Almagro, while third-seeded David Ferrer advanced with a 1-6, 7-5, 6-2 come-from-behind victory over former world No. 1 and fellow Spaniard Juan Carlos Ferrero. Ferrer staved off three match points before fighting back to win and secure a spot in the prestigious ATP World Tour Finals next month.
Ferrer and Roddick will square off on Friday.
In other third-round action, Ebden upended eighth-seeded Frenchman Gilles Simon 6-2, 2-6, 7-6 (10-8), 12th-seeded Ukrainian Alexandr Dolgopolov overcame rising Aussie teenager Bernard Tomic 5-7, 6-1, 6-0, and Japan's best, Kei Nishikori, held off Colombian Santiago Giraldo 7-6 (8-6), 4-6, 6-3. The world No. 47 Nishikori will become the highest-ranked Japanese player in the Open Era (since 1968) next week.
Nishikori will encounter the nifty Dolgopolov on Friday.
The 2011 Shanghai champion will earn $620,000.