DETROIT (Ticker) -- The Detroit Lions usually have success on Thanksgiving. Peyton Manning has success virtually every week.
Since relocating to Indianapolis in 1983, the Colts will play on Thanksgiving for the first time when they meet Detroit in an interconference game.
The Lions have won seven of their last 10 holiday games, including a 22-14 upset of Brett Favre and the Green Bay Packers in 2003.
But no quarterback is hotter than Manning, who is on pace to break Dan Marino's single-season NFL record of 48 touchdown passes in 1984. Manning has thrown for 35 touchdowns in 10 games and needs 14 over the last six to break Marino's mark. He had four, including a pair to Reggie Wayne, in the Colts' 41-10 rout of the Chicago Bears last week.
In 106 career games, Manning has passed for 202 touchdowns. Only Marino reached 200 TD passes in fewer games (89).
But the Lions don't have just Manning and his stable of receivers, led by Marvin Harrison and Wayne, to worry about. They also have to contend with Edgerrin James, who trampled the Bears for 204 yards on 23 carries before sitting out the fourth quarter.
Indianapolis has scored a league-high 339 points, an average of nearly 34 per game. No other NFL team has reached 300 points. Compare that to the Lions, who are averaging 18.3 points per game.
Joey Harrington threw for only 91 yards and was intercepted once in the Lions' 22-19 loss at Minnesota last week. It was the fourth straight loss for Detroit, which slipped two games behind co-leaders Green Bay and Minnesota in the NFC North.
The Lions' biggest offensive weapon has been Eddie Drummond, who scored on two punt returns in a 23-17 overtime loss at Jacksonville on November 14 and returned a kickoff 92 yards for a touchdown on the first play of last week's loss at Minnesota.
They will probably need another touchdown from Drummond on Thursday to have a chance to beat the Colts, who have a whopping total of 90 points in their last two games.
Lions cornerbacks Dre' Bly and Fernando Bryant will match up against Harrison and Wayne, who have combined for 98 catches for 1,379 yards and 17 touchdowns. Detroit also needs to cover slot receiver Brandon Stokley, who has 42 receptions for 672 yards and five scores.
Lions receiver Roy Williams has been hampered by a sprained ankle. He had just two catches for 19 yards last week.
Since 1934, Detroit has played 64 Thanksgiving Day games and posted a 33-29-2 record. The Colts were based in Baltimore when they played a 24-24 tie here on Thanksgiving in 1965.