The MMA legend will rematch Chris (All-American) Weidman in the main event of UFC 168 in Las Vegas Dec. 28. The card will also feature a women's bantamweight title bout between Ronda Rousey and Miesha Tate.
UFC president Dana White confirmed the booking on Saturday’s edition of ESPN SportsCenter.
"This fight between Anderson Silva and Chris Weidman will be the biggest fight in history," White said. "This is the biggest fight out there right now, and that’s saying a lot."
Weidman shocked the MMA world by ending Silva's legendary title run via a stunning second-round KO at UFC 162 in Las Vegas last weekend.
The KO came amid Silva taunting Weidman while jawing at him non-stop and daring him to make a move.
In total, the Brazilian held the belt for 2,458 days.
The bout marked the first time Silva had been finished since a submission defeat to Ryo Chonan on Dec. 31, 2004.
Immediately following the loss to Weidman, Silva claimed he wouldn't sign on for a rematch.
“I finish my work,” Silva said in the cage. “I no more fight for the belt. I fight for the belt for a long time. I'm tired.”
It didn't take long for him to change his tune.
"(It is) a bad feeling. In fact, I still have it,” Silva recently told GQ Brazil. “(I) had never been knocked out in my career. I did not like it. The most important thing for me was to realize that people like me and want to see me always winning. But it was also important to reiterate that I am not invincible. Nobody is. Everyone has bad days.”