"I would be guessing," said Bulls coach Tom Thibodeau when asked if he knew what it was.
Before he left, Rose shook off an early funk to get 23 points, nine rebounds and nine assists as the Bulls opened their second straight postseason as the NBA's No. 1 overall seed.
A few runs here and there was all it took to keep the Sixers at bay, despite Evan Turner's contention that his team lucked out by drawing the Bulls instead of the Miami Heat.
The Bulls were up 12 points when Rose went down. He was set to have an MRI.
"I sure hope he's not seriously hurt," said Sixers coach Doug Collins. "I admire him so much. He's one of the bright lights in the NBA."
Richard Hamilton scored 19 points, Luol Deng had 17 and Joakim Noah added 12 points and 13 rebounds for the Bulls, who also had the No. 1 overall seed last year but were eliminated by the Heat in the Eastern Conference finals.
Elton Brand had 19 points and seven rebounds to lead the Sixers. Jrue Holiday scored 16, Thaddeus Young added 13 and Turner had 12 points.
The Sixers scored six straight points to open the second half, climbing within five, but Rose led a 9-0 Bulls run that allowed the favorites some breathing room.
He scored five straight points during the burst on a pair of free throws and a three-pointer, then knocked down another three midway through the quarter to make it a 14-point game.
The lead reached as high as 16 and was 79-66 going into the fourth quarter.
Things got physical late in the third after Bulls forward Carlos Boozer bumped into Turner during a stoppage. Following some pushing and shoving, Rose and Hamilton for the Bulls and Brand for the Sixers were all called for technical fouls.
No punches were thrown, but Turner was booed often by the Chicago crowd after telling a newspaper this week that the Sixers were "dodging the tougher team" by drawing the Bulls instead of the Heat in the first round.
Turner, who is from Chicago, was probably referring to the Sixers' 0-4 record against the Heat in the regular season. They were 1-2 against the Bulls, who went up by as many as 20 points in the fourth quarter of this one and shot 51.3 percent for the game.
"That was the best they've played us all season," Collins said.
The Bulls, who had a 28-24 lead after the first quarter, also made a 9-0 run with Rose on the bench after the Sixers tied the game in the second.
Deng scored the first five points, including a three to spark the burst, and Chicago pushed its lead to 37-28.
Rose was just 5-of-13 for 10 points in the first half, but the Bulls led by as many as 13 late and took a 53-42 advantage into the break after shooting 52.3 percent.
The Bulls went 50-16 and would have homecourt advantage through the NBA Finals...The Sixers went 35-31 for the No. 8 seed. They shot 39.8 percent in Game 1.
Final Score: Miami 100, New York 67
Miami, FL - Still searching for his first NBA championship, LeBron James opened the 2012 playoffs by scoring 32 points on just 14 shots and the Miami Heat dominated the New York Knicks, 100-67, in Game 1 of the Eastern Conference quarterfinals on Saturday. James made 10 of his 14 field goal attempts and 11-of-14 free throws, Dwyane Wade scored 19 points and Mario Chalmers contributed 11 for the Heat, who won their fourth straight over New York to take the early advantage in the best-of-seven series. J.R. Smith led the way with 17 points off the bench for the Knicks, who committed 27 turnovers and 26 fouls. Carmelo Anthony scored 11 points with 10 rebounds but shot just 3-of-15 from the floor.
Final Score: Orlando 81, Indiana 77
Indianapolis, IN - Jason Richardson buried the go-ahead three-pointer, part of a run of 11 unanswered Magic points to the end the game, as Orlando rallied to take Game 1 of the Eastern Conference quarterfinals, 81-77, over the Indiana Pacers on Saturday. Despite lacking the presence of three-time Defensive Player of the Year Dwight Howard -- sidelined with season-ending back surgery -- Orlando prevented Indiana from scoring in the game's final 4:05. Glen Davis had 16 points to go with 13 rebounds while Richardson and Jameer Nelson finished with 17 points apiece for the Magic, who have won five in a row at Bankers Life Fieldhouse. Roy Hibbert's career-high nine blocks for Indiana tied for the second-most in NBA playoff history, and David West led all scorers with 19 points, but the Pacers missed their final nine shots to drop the first test in this best-of- seven series. Game 2 will take place on Monday.
Final Score: Oklahoma City 99, Dallas 98
Oklahoma City, OK - Kevin Durant's go-ahead jumper with 1.5 seconds remaining lifted the Oklahoma City Thunder past the Dallas Mavericks, 99-98, in Game 1 of this Western Conference quarterfinal.
After Dirk Nowitzki gave Dallas the lead with a pair of free throws with nine seconds remaining in the contest, Durant heaved a high-arcing, off-balanced floater from the foul line over the outstretched arms of two Dallas defenders.
The ball bounced high off the front of the rim, tantalizing the Oklahoma City faithful before falling through the net and sending the home crowd into complete euphoria.
Durant finished the game with 25 points on 10-of-27 shooting from the field for the Thunder, who fell to the Mavericks in five games in last year's Western Conference Finals.
Nowitzki netted 25 points to pace Dallas.